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Product

CD275 [B7-H2] (human):Fc (mouse) (rec.)

Product Data

Synonyms : 

B7-H2; B7H2; B7RP-1; B7RP1; CD275; B7-like Protein Gl50; ICOSL

Properties

Host : 

CHO cell

Sequence : 

The extracellular domain of human CD275[B7-H2] (NP_056074.1) (Met1-Thr256) is fused to the 

N-terminus of the Fc region of mouse IgG2a. 

Molecular Mass:

53KDa (monomer)

Purity :

>90%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/μg as determined by LAL test.

 

 

Activity:

Measured by its binding ability in a functional ELISA.

 

 

 

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.


Documents
Description

Human B7-H2,also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of

immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1(PD-L1), PD-L2, and

B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains

contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members,

they share about 20-25% amino acid identity. Human and mouse B7-H2 share approximately 49% amino

acid identity. B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of

costimulatory receptors. Human B7-H2 is a 309 amino acid (aa) protein with a putative 18 aa signal

peptide, a 239 aa extracellular domain, an 18 aa transmembrane region, and a 33 aa cytoplasmic

domain. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells, and at low levels on

monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and T h

differentiation.

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