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CD273 [PD-L2] (human):Fc (human) (rec.) (non-lytic)

Product Data

Synonyms : 

PD-L2; Programmed Cell Death 1 Ligand 2; 

PDCD1 Ligand 2; B7-DC; PDL2


Host : 

CHO cell 

Sequence :

The extracellular domain of human CD273 [PD-L2] (NP_079515.2) (Leu20-Pro219) 

is fused to the N-terminus of the Fc region of a mutant human IgG1. 

Molecular Mass:

48.6KDa (monomer)


Acts as a long lasting fusion protein which only binds to the receptor. 

Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins 

incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).



Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60EU/mg as determined by LAL test.




Measured by its binding ability in a functional ELISA.

Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :


Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.



T cells require a signal induced by the engagement of the T cell receptor and a “costimulatory” signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 [PD-L2] is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.

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